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A breakthrough in type 1 diabetes management

twiist is a groundbreaking automated insulin delivery (AID) system that puts you in control with advanced features designed to personalize how you manage your type 1 diabetes.

With flexible wear options, discreet design, and a 300-unit insulin capacity, the twiist Pump is built for both convenience and peace of mind.
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Powered by Tidepool, the twiist AID System offers the widest glucose target range available and gives you the freedom to manage your insulin directly from your iPhone and optional, connected Apple Watch.1

Adhesive options for on-body wear are currently being developed

twiist your way

Manage your type 1 diabetes your way with adaptive and predictive insulin delivery technology from the twiist AID System.

  • Customizable Glucose Target(s) can be set between 87-180 mg/dL, the widest correction range of any available AID system, so you can stay in the range that is right for you.1,3-7
  • Auto Adjust powered by twiist Loop‡ updates your 6-hour glucose prediction every 5 minutes, and adjusts basal insulin all day and night to help prevent highs and lows.1
  • iiSure™ ensures precise insulin delivery down to the microdose and detects blockages up to 9x faster than any other AID systems, potentially reducing unexpected highs.2
  • The small but mighty twiist Pump weighs less than 2oz, and holds 300 units, making it the smallest available pump with such a large capacity.1, 3-7

A system as unique as you are

The twiist AID System is uniquely designed to adapt to the changes in your day to help prevent highs and lows.

  • Change your mind. Sometimes you eat more or less than expected. When plans change, you can update carb entries up or down before, during, and even after eating, and twiist will adjust basal insulin delivery.
  • Calculate beyond carbs. Different foods can impact glucose levels differently. Some raise glucose quickly,
while others do so more slowly. With twiist, you can optimize your insulin delivery to the types of food you are eating for smoother, more precise blood sugar control.
Ready for an insulin delivery system that’s in tune with you?
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twiist smarter, not harder

The twiist AID System updates predictions every 5 minutes to create a 6-hour glucose forecast.1

Recalculates

These predictions are calculated using your CGM readings, personalized settings, insulin delivery history, and carb history.

level selectors
Adjusts

Based on these predictions, twiist automatically adjusts basal insulin delivery every five minutes, so glucose will ultimately meet your personal correction target.

Helps prevent highs and lows

twiist automatically adjusts your basal insulin delivery in an effort to reach your target glucose and help prevent highs and lows.

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Put a new twiist on how you manage your type 1 diabetes.
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INDICATIONS FOR USE1

The twiist system is intended for the subcutaneous delivery of insulin, at set and variable rates. for the management of diabetes mellitus in persons requiring insulin, ages six and above. The pump is able to reliably and securely communicate with compatible. digitally connected devices. including automated insulin dosing software. to receive, execute. and confirm commands from these devices. The twiist system is intended for single patient. home use and requires a prescription.

The twiist Loop algorithm. is intended for use with compatible integrated continuous glucose monitors (iCGM) and the twiist alternate controller enabled (ACE) insulin infusion pump to automatically increase, decrease. and suspend delivery of basal insulin based on iCGM readings and predicted glucose values. It can also recommend, and with the user's confirmation. deliver correction boluses when glucose values are predicted to exceed user configurable thresholds. The twiist Loop algorithm is intended for the management of type 1 diabetes mellitus in persons six years of age and greater. and is intended for single-patient use.The twiist automated insulin delivery system is for prescription use only.

The twiist Automated Insulin Delivery System includes a simple bolus calculator available when Loop is off. It is indicated for use for aiding the user in determining the bolus insulin dosage for management of diabetes mellitus based on consumed carbohydrates, operator entered blood glucose, insulin sensitivity, insulin to carbohydrate ratio. target glucose values. and current insulin on board.
REFERENCES

1. Sequel Med Tech - twiist Automated Insulin Delivery (AID) System Powered by Tidepool User Guide 2. Calculation based on a comparison of the following IF Us. The following reported 1 U/hr basal rate Sequel Med Tech - twiist Automated Insulin Delivery (AID) System Powered by Tidepool User Guide: lnsulet - Omni pod 5 Automated Insulin Delivery System User Guide: Medtronic - MiniMed 780G system User Guide : Beta Bionics - iLet Bionic Pancreas System User Guide. The following reported 2 U/hr basal rate: Tandem Diabetes Care - t:slim X2 Insulin Pump User Guide: Tandem Diabetes Care - Tandem Mobi System User Guide.3. lnsulet - Omnipod 5 Automated Insulin Delivery System User Guide 4.Medtronic - MiniMed 780G system User Guide 5. Beta Bionics - iLet Bionic Pancreas System User Guide 6. Tandem Diabetes Care - t:slim X2 Insulin Pump User Guide 7 Tandem Diabetes Care - Tandem Mobi System User Guide 8 .. Lum JW, et al. A Real-World Prospective Study of the Safety and Effectiveness of the Loop Open Source Automated Insulin Delivery System Diabetes Technol Ther 2021:23(5):367-75. 9. Klonoff DC, et al. Time to Moderate and Severe Hyperglycemia and Ketonemia Following an Insulin Pump Occlusion. J Diabetes Sci Technol 2024. 10. Wong JJ, et al PsychosocialEffects of the Loop Open-Source Automated Insulin Delivery System. J DiabetesSci Technol 2023; 17(6):1440-7 11. Butterfield RD, et al. Performance of aContinuous Subcutaneous Insulin Infusion (CSII) Pump with Acoustic Volume andFlow Sensing in Simulated High-Consequence Situations. IEEE Open J Eng Med Biol2024;PPl99) 1-7..

*The twiist™ Savings Program is available to individuals with a valid prescription and commercial insurance that covers twiist. Eligible participants can receive a Starter Kit for $0 and pay no more than $50 for Refill Kits. This offer is not valid for individuals enrolled in Medicare, Medicaid, or any other federal or state programs, or for cash-paying patients and non-covered claims. It is available only in the U.S. and is not valid in Puerto Rico, U.S. Territories, or where prohibited by law. While most commercially insured participants qualify for the $50 Refill Kit offer, those with high-deductible plans who haven't met their deductible may pay more than $50 per Refill Kit until their deductible is met. The maximum benefit is $200 per Refill Kit for covered claims. Terms are subject to change. Call us at 1-877-489-4478 or contact your insurance provider to confirm coverage.  

† Adhesive options for on body wear are currently being developed.

‡Results obtained with the Loop algorithm using a non-twiist device

CONTRAINDICATIONS1

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The twiist AID System is not intended for anyone unable or unwilling to:

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  • Test blood glucose (BG) levels as recommended by their healthcare provider
  • Maintain sufficient diabetes selfcare skills.
  • See their healthcare provider regularly
  • Demonstrate adequate carbohydrate-counting skills (preferred, not required).

The user must not:

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  • Have difficulty seeing
  • Have difficulty hearing
  • Have deficient cognitive capabilities
  • Have physical impairments that would make operating the pump or iPhone difficult

Product not yet available outside of the U.S.
For full FreeStyle Libre 3 Plus sensor safety information, please visit https://www.freestyle.abbott/us-en/safety-information.html.
The sensor housing, FreeStyle, Libre, and related brand marks are marks of Abbott and used with permission.

“twiist,” “iiSure,” and the twiist logo are licensed trademarks of Sequel Med Tech, LLC. “Tidepool” and the Tidepool logo are trademarks of Tidepool Project, a fully-qualified 501(c)(3) nonprofit organization.
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