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Looks and works like no other AID system around.
See how twiist™ can help your patients better manage their type 1 diabetes (T1D) with greater personalized control, advanced technology, and simplified access.1-7
Get your patients started
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See how twiist™ can help your patients better manage their type 1 diabetes (T1D) with greater personalized control, advanced technology, and simplified access.1-7
Get your patients started
Refer Now

Empower your patients
‍with the twiist AID System

twiist personalizes T1D care by offering your patients advanced technology with precision and flexibility to adapt to their day. Patients can start twiist for $0 for the first month and they’ll pay no more than $50 a month after that.*
Greater Personalized Control
From retroactive carb entry capabilities and 3 bolusing options, to a 300 unit capacity and the widest glucose target range available (87-180 mg/dL),1,3-7 each feature is designed to help provide tighter glucose control by letting patients adapt settings to their daily needs.
Advanced Technology
twiist can help reduce the risk of unexplained hyperglycemia by detecting occlusions faster, so patients can take action sooner.2† By using iiSure™ sound wave technology, it detects occlusions up to 9x faster than other AID systems.2
Simplified Access
Most patients will pay $0 for the first month and no more than $50 per month after that, making cost less of a prescribing barrier.*
Get to know the many features of twiist
twiist provides more options for personalization to help your patients achieve tight glucose management.1,3-7
Greater Personalized Control
‍Adapts to patients' needs
  • Auto Adjust fine-tunes insulin delivery every 5 minutes to help meet user-specified correction target
  • Carb absorption rate lets patients specify if they've eaten slow-, medium-, and fast-absorbing carbs
Designed for flexibility
  • The smallest size pump to hold 300 units of insulin, weighs just 2 oz1,3-7
  • Multiple wear options (fits in pocket, clips to belt, or uses an adhesive patch‡)
  • Choice of compatible continuous glucose monitor
  • Three ways to bolus: directly from the pump or with a compatible smartphone or smartwatch
Advanced Technology
Novel confidence features
  • Potentially reduces the risk of unexplained hyperglycemia and DKA by detecting occlusions faster2†
  • Unique iiSure™ technology can detect occlusions up to 9x faster than other AID systems2
Simplified Access:
Support for your patients and your team
  • Most patients will pay $0 for the first month and no more than $50 per month after that*
  • With 70% of commercial insurance providers covering twiist, more patients have access to personalized, reliable insulin delivery
  • Patients can start using twiist even if they are still under contract with their previous pump
  • Extensive product and patient support
*The twiist™ Savings Program is available to individuals with a valid prescription and commercial insurance that covers twiist. Eligible participants can receive a Starter Kit for $0 and pay no more than $50 for Refill Kits. This offer is not valid for individuals enrolled in Medicare, Medicaid, or any other federal or state programs, or for cash-paying patients and non-covered claims. It is available only in the U.S. and is not valid in Puerto Rico, U.S. Territories, or where prohibited by law. While most commercially insured participants qualify for the $50 Refill Kit offer, those with high-deductible plans who haven't met their deductible may pay more than $50 per Refill Kit until their deductible is met. The maximum benefit is $200 per Refill Kit for covered claims. Terms are subject to change. Call us at 1-877-489-4478 or contact your insurance provider to confirm coverage.
†Klonoff DC, et al. Time to Moderate and Severe Hyperglycemia and Ketonemia Following an Insulin Pump Occlusion. J Diabetes Sci Technol 2024
‡Sequel is working on adhesive options for on-body wear. Alternative adhesive options are available through third-party providers.

Discover more about the novel features of twiist

See how twiist can help your patients better manage their T1D
Learn More
Get your patients started
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Adhesive options for on-body wear are currently being developed.
Personalized Diabetes Control
Product
Product Overview
Technology
Loop AlgorithmiiSure technology
Clinical Data
Study DataResources
Prescribing
Prescribing twiist
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INDICATIONS FOR USE1
The twiist system is intended for the subcutaneous delivery of insulin, at set and variable rates, for the management of diabetes mellitus in persons requiring insulin, ages six and above. The pump is able to reliably and securely communicate with compatible, digitally connected devices, including automated insulin dosing software, to receive, execute, and confirm commands from these devices. The twiist system is intended for single patient, home use and requires a prescription. 

The twiist Loop algorithm, is intended for use with compatible integrated continuous glucose monitors (iCGM) and the twiist alternate controller enabled (ACE) insulin infusion pump to automatically increase, decrease, and suspend delivery of basal insulin based on iCGM readings and predicted glucose values. It can also recommend, and with the user’s confirmation, deliver correction boluses when glucose values are predicted to exceed user configurable thresholds. The twiist Loop algorithm is intended for the management of type 1 diabetes mellitus in persons six years of age and greater, and is intended for single-patient use.The twiist automated insulin delivery system  is for prescription use only . 

The twiist automated insulin delivery system simple bolus calculator, available when Loop is off, is indicated for use for aiding the user in determining the bolus insulin dosage for management of diabetes mellitus based on consumed carbohydrates, operator-entered blood glucose, insulin sensitivity,  carbohydrate ratio, correction range, and current active insulin.
REFERENCES

1. The twiist Automated Insulin Delivery (AID)System Powered by Tidepool User Guide, Sequel Med Tech: DKPI-09233-001-EN 1.72024-10-21
2. Calculation based on a comparison of the following IFUs. The following reported 1 U/hr basal rate: The twiist Automated Insulin Delivery (AID) System Powered by Tidepool User Guide, Sequel Med Tech(DKPI-09233-001-EN 1.7 2024-10-21). Omnipod 5 Technical User Guide (PT-000941-AW Rev07 10/24), MiniMed 780G System User Guide (M036461C001_22023-02-24). iLet Bionic Pancreas System User Guide (LA000081_E 3-19-24). The following reported 2 U/hr basal rate: t:slim X2 Insulin Pump User Guide (AW-1011648_B 2023-Nov-09), Tandem Mobi System User Guide (AW-1012691_A2023-Dec-07.)
3. Omnipod 5 Technical User Guide. Insulet Corporation; PT-000941-AW Rev. 07 10/24
4. MiniMed 780G with the Guardian. Sensor System User Guide, Medtronic: M036461C001_2 2023-02-24.
5. iLet Bionic Pancreas System Quick Reference Guide, Beta Bionics: LA000082_E.
6. t:slim X2 Insulin Pump with Control-IQ Technology User Guide, Tandem Diabetes Care: AW-1011648_B 2023-Nov-09.
7. Tandem Mobi System, Tandem Diabetes Care: AW-1012691_A 2023-Dec-07.
8. Lum JW, Bailey RJ, Barnes-Lomen V, et al. A real-world prospective study of the safety and effectiveness of the Loop open source automated insulin delivery system. Diabetes Technol Ther. 2021;23(5):367-375.
9. Wong JJ, et al. Psychosocial Effects of the Loop Open-Source Automated Insulin Delivery System. J Diabetes Sci Technol 2023;17:1440–7.
10. R. D. Butterfield and N. M. Sims, “Performance of a Continuous Subcutaneous Insulin Infusion (CSII) Pump with Acoustic Volume and Flow Sensing in Simulated High Consequence Situations,” in IEEE Open Journal of Engineering in Medicine and Biology, doi: 10.1109/OJEMB.2024.3408092.

Product not yet available outside of the U.S.
CONTRAINDICATIONS

The twiist automated insulin delivery system is not intended for anyone unable or unwilling to:

  • Test blood glucose (BG) levels as recommended by their healthcare provider.
  • Maintain sufficient diabetes selfcare skills.
  • See their healthcare provider regularly.
  • Demonstrate adequate carbohydrate-counting skills (preferred, not required).

The user must not:

  • Have difficulty seeing.
  • Have difficulty hearing.
  • Have deficient cognitive capabilities.
  • Have physical impairments that would make operating the pump or iPhone difficult.
For full FreeStyle Libre 3 Plus sensor safety information, please visit https://www.freestyle.abbott/us-en/safety-information.html.
The sensor housing, FreeStyle, Libre, and related brand marks are marks of Abbott and used with permission.

“twiist,” “iiSure,” and the twiist logo are licensed trademarks of Sequel Med Tech, LLC. “Tidepool” and the Tidepool logo are trademarks of Tidepool Project, a fully-qualified 501(c)(3) nonprofit organization.
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